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post in: Facts Date:29 Oct 2012, 22:14 views:1812
Nucleic Acids, Proteins, and Antibodies 001 This application refers to a "Sequence Listing" that is provided only on electronic media in computer readable form pursuant to Administrative Instructions Section 801(a i). The Sequence Listing forms a part of this description pursuant to Rule.2 and Administrative Instructions Sections 801 to 806, and is hereby incorporated in its entirety.
002 The Sequence Listing is provided as an electronic file (PA120PCT_seqList. Txt, 7,005,066 bytes in size, created on January 12, 2001) on four identical compact discs (CD-R labeled "copy 1 "copy 2 "copy 3 and "CRF." The Sequence Listing complies with Annex C ofthe Administrative Instructions, and maybe viewed, for example, on an IBM-PC machine running.
Field ofthe Invention 003 The present invention relates to novel testes related polynucleotides, the polypeptides encoded by these linea polynucleotides herein collectively referred to as "testicular antigens and antibodies that immunospecifically bind these polypeptides, and the use of such testicular polynucleotides, antigens, and antibodies for detecting. More specifically, isolated testicular nucleic acid molecules are provided encoding novel testicular polypeptides. Novel testicular polypeptides and antibodies that bind to these polypeptides are provided.
Also provided are vectors, host cells, and recombinant and synthetic methods for producing human testicular polynucleotides, polypeptides, and/or antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the testes, including testicular cancer, and therapeutic methods for treating such disorders.
The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The invention further relates to methods and/or compositions for inhibiting or promoting the production and/or function of the polypeptides ofthe invention. Background ofthe Invention 004 The two primary functions of the testes are 1) production of testosterone and 2) production of sperm.
Testosterone produced in the testes is released into the blood stream, where it travels to and acts on a wide range of tissues and organs within the male body. Disorders resulting from testosterone deficiency are manifested in the male reproductive system typically by symptoms of hypogonadism, which is the failure to go through puberty.
Specifically, erectile function is impaired, as well as libido and sperm production. 005 Known dysfimctions of sperm production include aspermia (the failure to produce an ejaculate asthenospermia (the production of an ejaculate in which less than 50 of spermatozoa are motile azoospermia (the production of an ejaculate devoid of spermatozoa oligospermia (production of an ejaculate containing less.
Improper sperm formation may result from a variety of factors, including congenital defects, genetic abnormalities, injury, and infection. For example, contraction of the mumps virus early in male adolescence can infect the testicles, leading to permanent complications in sperm production.